Commentaries:
Could it be that this provides insight into the only thing He feared—the loss of contact and communication with His Father—and that He did not know what He would do then?
We need to consider this deeply and appreciatively because this is the great gift made available to us by Christ's sacrifice. Fellowship with God, being at peace with Him, and having access to Him are admittance to the very fountain of living waters. We can safely say that, once our sins are covered by Christ's blood, access to God is the source of all spiritual strength and growth because the love of God is poured out in our hearts by the Holy Spirit given to us (Romans 5:1-5).
John W. Ritenbaugh
The Offerings of Leviticus (Part Six): The Sin Offering
Jesus quoted His own words, which He had inspired His servant David to put into writing a thousand years before this day, when He cried, "My God, My God, why have You forsaken Me?" (Psalm 22:1). By repeating it as He hung on the stake, He declared this prophecy to be fulfilled at that very moment; the absolute peak of the agony that He and His Father had planned and foreknew had arrived. Even in His delirium, the utterances of the Logos were solidly based upon His own Word!
John Plunkett
Jesus' Final Human Thoughts (Part Two)
Other commentary entries containing this verse:
Isaiah 52:14